{"id":729,"date":"2022-07-20T13:21:34","date_gmt":"2022-07-20T10:21:34","guid":{"rendered":"https:\/\/omerkaradag.com\/?p=729"},"modified":"2022-07-28T12:40:17","modified_gmt":"2022-07-28T09:40:17","slug":"otoimmun-hastalik-nedir","status":"publish","type":"post","link":"https:\/\/omerkaradag.com\/en\/otoimmun-hastalik-nedir\/","title":{"rendered":"Otoimm\u00fcn Hastal\u0131k Nedir? Ba\u011f Dokusu Hastal\u0131\u011f\u0131 Nedir? \u0130mm\u00fcn Sistem Ne \u0130\u015fe Yarar?"},"content":{"rendered":"
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Otoimm\u00fcn Hastal\u0131k Nedir? Ba\u011f Dokusu Hastal\u0131\u011f\u0131 Nedir? \u0130mm\u00fcn Sistem Ne \u0130\u015fe Yarar?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"otoimm\u00fcn-hastal\u0131k\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Prof. Dr. \u00d6mer Karada\u011f taraf\u0131ndan yaz\u0131lm\u0131\u015ft\u0131r.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Bu yaz\u0131y\u0131 a\u015fa\u011f\u0131daki butonlar\u0131 kullanarak ba\u015fkalar\u0131yla payla\u015fabilirsiniz.<\/em><\/h4>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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V\u00fccudumuz, \u00e7ok \u00e7e\u015fitli dokular\u0131n bir uyum i\u00e7erisinde \u00e7al\u0131\u015ft\u0131\u011f\u0131 ola\u011fan\u00fcst\u00fc bir makine gibidir. Bu sistem i\u00e7erisinde cilt, kemik, eklem, kaslar\u0131n yan\u0131 s\u0131ra b\u00f6brek, akci\u011fer ve beyin ile sinir h\u00fccreleri gibi \u00e7ok \u00e7e\u015fitli ve \u00f6zelle\u015fmi\u015f h\u00fccreler bulunmaktad\u0131r. Belirtti\u011fimiz bu \u00e7e\u015fitli dokular\u0131 bir arada tutarak onlar\u0131 destekleyen dokulara \u2018Ba\u011f dokusu\u2019<\/strong> denilmektedir. Di\u011fer ad\u0131 Konnektif dokudur<\/strong>.<\/p>

V\u00fccudumuz, kendisini \u00e7evreden gelen mikrop ve yabanc\u0131 maddelere kar\u015f\u0131 korumak i\u00e7in ba\u011f\u0131\u015f\u0131kl\u0131k sistemine (imm\u00fcn sistem<\/strong>) sahiptir. Ba\u011f\u0131\u015f\u0131kl\u0131k sistemi normalde kendi h\u00fccrelerine kar\u015f\u0131 faaliyet g\u00f6stermez.<\/strong><\/p>

Ancak tam olarak nedenlerini bilemedi\u011fimiz sebeplerden dolay\u0131 kendi dokular\u0131na kar\u015f\u0131 faaliyet g\u00f6stermeye ba\u015flay\u0131nca bu h\u00fccrelere zarar verir.<\/p>

Cilt dokusuna kar\u015f\u0131 faaliyet g\u00f6sterdi\u011finde cilt d\u00f6k\u00fcnt\u00fcs\u00fc ve yaralar; ekleme kar\u015f\u0131 faaliyet g\u00f6sterdi\u011finde eklemde a\u011fr\u0131 ve \u015fi\u015flik- k\u0131zar\u0131kl\u0131\u011fa yol a\u00e7abilir. B\u00f6brek dokusuna zarar vermesi durumunda b\u00f6brekler yeterli s\u00fczme yapamaz ve b\u00f6brek yetmezli\u011fine bile yol a\u00e7abilir.<\/p>

Bu tarz hastal\u0131klara genel olarak \u2018Otoimm\u00fcn hastal\u0131klar\u2019<\/strong> diyoruz.<\/p>

Otoimm\u00fcn hastal\u0131klara \u00f6rnek olarak Lupus veya SLE olarak bilinen hastal\u0131k verilebilir. Yine t\u00fckr\u00fck bezlerini tutmas\u0131yla bilinen Sj\u00f6gren sendromu, ciltte sertle\u015fme ve damarlar\u0131n\u0131n fonksiyon bozuklu\u011fuyla giden sistemik skleroz (skleroderma) da bu grup i\u00e7inde yer almaktad\u0131r.<\/p>

\u0130ltihapl\u0131 romatizmal hastal\u0131klar\u0131n genel \u00f6zelli\u011fi, tutulan dokulardan par\u00e7a al\u0131nd\u0131\u011f\u0131nda (biyopsi yap\u0131ld\u0131\u011f\u0131nda), iltihap g\u00f6sterilebilmektedir.<\/p>

Ba\u011f dokusu hastal\u0131klar\u0131n\u0131n olu\u015fmas\u0131nda geneti\u011fin rol\u00fc var m\u0131? \u00c7evresel ve ki\u015fisel fakt\u00f6rler rol oynuyor mu?<\/strong><\/h4>

Otoimm\u00fcn hastal\u0131klar\u0131n geli\u015fiminde, altta yatan genetik zemin olmas\u0131 \u015fart de\u011fildir. Ancak ailede iltihapl\u0131 romatizmal hastal\u0131k olmas\u0131, ki\u015filerde otoimm\u00fcn hastal\u0131k i\u00e7in yatk\u0131nl\u0131\u011f\u0131 artt\u0131rmaktad\u0131r.<\/p>

Otoimm\u00fcn hastal\u0131klar nas\u0131l geli\u015fir? <\/strong><\/h4>

Genel olarak genetik zemini olan ki\u015filerde \u00e7evresel ve v\u00fccudun yap\u0131s\u0131ndan kaynaklanan (hormonal, sigara stres vb.) nedenlerin tetiklemesiyle imm\u00fcn sistemin \u00e7al\u0131\u015fmas\u0131nda d\u00fczensizlikler olabilir. Bunun sonucunda normalde kendi dokular\u0131na kar\u015f\u0131 faaliyet g\u00f6stermeyen imm\u00fcn sistem, kendi dokular\u0131na kar\u015f\u0131 faaliyet g\u00f6stermeye ba\u015flar. Hatta otoimm\u00fcn antikorlar olarak bilinen ANA, CCP ve dsDNA gibi tetkikleri bireylerin serumlar\u0131nda saptanmaya ba\u015flar.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Otoimm\u00fcn Hastal\u0131k Nedir? Ba\u011f Dokusu Hastal\u0131\u011f\u0131 Nedir? \u0130mm\u00fcn Sistem Ne \u0130\u015fe Yarar? Prof. Dr. \u00d6mer Karada\u011f taraf\u0131ndan yaz\u0131lm\u0131\u015ft\u0131r. Bu yaz\u0131y\u0131 a\u015fa\u011f\u0131daki butonlar\u0131 kullanarak ba\u015fkalar\u0131yla payla\u015fabilirsiniz. V\u00fccudumuz, \u00e7ok \u00e7e\u015fitli dokular\u0131n bir…<\/p>","protected":false},"author":1,"featured_media":730,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-hastaliklar"],"_links":{"self":[{"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/posts\/729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/comments?post=729"}],"version-history":[{"count":5,"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/posts\/729\/revisions"}],"predecessor-version":[{"id":891,"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/posts\/729\/revisions\/891"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/media\/730"}],"wp:attachment":[{"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/media?parent=729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/categories?post=729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/omerkaradag.com\/en\/wp-json\/wp\/v2\/tags?post=729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}